New Data from Sanjay Gandhi Post Graduate Institute of Medical Science Illuminate Findings in Gallbladder Cancer

Current study results on Oncology have been published. According to news reporting originating from Uttar Pradesh, India, by VerticalNews correspondents, research stated, "PSCA is a tissue specific tumor suppressor or oncogene which has been found to be associated with several human tumors includinggallbladder cancer. It is considered to be involved in the cell-proliferation inhibition and/or cell-death induction activity."

Our news editors obtained a quote from the research from the Sanjay Gandhi Post Graduate Institute ofMedical Science, "Therefore, we aimed to investigate the role of PSCA gene polymorphisms in gallbladder cancer risk in North Indian population. A total of 405 gallbladder cancer patients and 247 healthy controls were included in the case-control study for risk prediction. We examined the association of two functional SNPs, rs2294008 and rs2978974 in PSCA gene by genotyping using Taqman allelic discrimination assays. Statistical analysis was done using SPSS software, version 17. Linkage disequilibrium and haplotype analysis was done with the help of SNPstats software. FDR test was used to correct for multiple comparisons. No significant associations of rs2294008 and rs2978974 genetic variants of the PSCA gene were found with GBC risk at allele, genotype or haplotype levels. Stratifying the subjects on the basis of gallstone also did not show any significant result. However, on gender stratification, we found a significant association of T-rs2294008-G(rs2978974) haplotype with higher risk of GBC in females (FDR Pcorr = 0.021, OR = 1.6). In contrary, T-rs2294008-A (rs2978974) haplotype conferred significant lower risk in males (FDR Pcorr = 0.013; OR = 0.25)."

Source: http://www.hispanicbusiness.com/2013/11/13/new_data_from_sanjay_gandhi_post.htm